2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor

Angiotensin Receptor

Angiotensin Receptor

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Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Isoform Specific Products:

Angiotensin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101823A
    A-81282
    		Antagonist
    A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats.
    A-81282
  • HY-106890
    E4177
    		Antagonist
    E4177 (57G709) is an orally active angiotensin II receptor antagonist. E4177 can inhibit the growth of vascular smooth muscle cells (HASMC) and the increase of cell surface area. In addition, E4177 can also increase the expression of platelet-derived growth factor (PDGF) receptor. E4177 can be used in the study of vascular diseases.
    E4177
  • HY-139373
    2-(Aminomethyl)-4-methylphenol hydrochloride
    		Inhibitor
    2-(Aminomethyl)-4-methylphenol (5-methyl-2-HOBA) hydrochloride is an isoketal scavenger that attenuates the hypertensive response to angiotensin II.
    2-(Aminomethyl)-4-methylphenol hydrochloride
  • HY-102093R
    ZD 7155(hydrochloride) (Standard)
    		Antagonist
    ZD 7155(hydrochloride) (Standard) is the analytical standard of ZD 7155(hydrochloride). This product is intended for research and analytical applications. ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
    ZD 7155(hydrochloride) (Standard)
  • HY-167853
    KR-31080
    		Inhibitor
    KR-31080 is an derivative of imidazo [4,5-b] pyridine. KR-31080 inhibits angiotensin II receptor. KR-31080 inhibits the NO production in LPS-stimulated BV-2 cells at a concentration of 2 μm with inhibition of 8.3%.
    KR-31080
  • HY-131276R
    Olmesartan lactone impurity (Standard)
    		Antagonist
    Olmesartan lactone impurity (Standard) is the analytical standard of Olmesartan lactone impurity. This product is intended for research and analytical applications. Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.
    Olmesartan lactone impurity (Standard)
  • HY-133775
    Olmesartan impurity
    		Antagonist
    Olmesartan impurity is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist has the potential for high blood pressure study.
    Olmesartan impurity
  • HY-167886
    GA 0113
    		Antagonist
    GA 0113 is a potent and orally active angiotensin II (Ang II) AT1-receptor antagonist. GA 0113 inhibits the Ang II (HY-13948)-induced pressor response with ID50 of 0.032 mg/kg and dose-dependently increases plasma renin activity for 48 h.
    GA 0113
  • HY-14736R
    Azilsartan medoxomil (Standard)
    		Antagonist
    Azilsartan medoxomil (Standard) is the analytical standard of Azilsartan medoxomil. This product is intended for research and analytical applications. Azilsartan medoxomil (TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
    Azilsartan medoxomil (Standard)
  • HY-120238
    RG 13647
    RG 13647 is an AT2-selective ligand. RG 13647 is an analog of PD 123177 (HY-121767). RG 13647 shows weak activity in competing for [125I]angiotensin II binding with an IC50 value of 100 μM. RG 13647 can be used for research of cardiovascular disease.
    RG 13647
  • HY-169221
    Perindopril arginine
    		Activator
    Perindopril arginine is an angiotensin-converting enzyme inhibitor with hypotensive activity. Perindopril arginine is used to inhibit hypertension to lower blood pressure. Perindopril arginine, when used in combination with indapamide and amlodipine, can effectively lower blood pressure and provide better target organ protection.
    Perindopril arginine
  • HY-U00245
    L162441
    		Antagonist
    L162441 is an Angiotensin type 1 receptor antagonist.
    L162441
  • HY-U00202
    LY285434
    		Antagonist
    LY285434 is a suitable angiotensin II receptor antagonist.
    LY285434
  • HY-U00188
    A81988
    		Antagonist
    A81988 is a potent, competitive, non-peptidic antagonist of angiotensin AT1 receptors.
    A81988
Cat. No. Product Name / Synonyms Application Reactivity
Angiotensin Receptor Isoform Comparison

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